Psychophysiological reactions in methadone maintenance patients do not correlate with methadone plasma levels

Autor(en)

Rainer Schmid, Reinhold Jagsch

Abstrakt

In methadone maintenance therapy methadone plasma concentrations of 400 ng/ml are necessary to suppress any further opiate action and to provide stabilized maintenance. In a controlled study we have searched for a differentiation in autonomous activation between patients having low and high methadone plasma levels, using static and dynamic pupillometry and habituation of skin conductance response. Results show that there is no difference in psychophysiological response between patients with high (>400 ng/ml) or low (<400 ng/ml) plasma levels of methadone. This indicates that there is no reduction in behavioral arousal in patients with high plasma methadone levels. On the basis of these findings, there is no rationale to maintain patients on plasma levels below 400 ng/ml.

Organisation(en)

Institut für Klinische und Gesundheitspsychologie

Externe Organisation(en)

Medizinische Universität Wien

Journal

Psychopharmacology

Band

103

Seiten

538-540

Anzahl der Seiten

3

ISSN

0033-3158

DOI

https://doi.org/10.1007/BF02244255

Publikationsdatum

04-1991

Peer-reviewed

Ja

ÖFOS 2012

501010 Klinische Psychologie

Schlagwörter

ASJC Scopus Sachgebiete

Pharmacology

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/psychophysiological-reactions-in-methadone-maintenance-patients-do-not-correlate-with-methadone-plasma-levels(68ebf656-b022-4037-906f-8f4bc8ad01a8).html