Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults
- Autor(en)
- Sonia Turrini, Naomi Bevacqua, Antonio Cataneo, Emilio Chiappini, Francesca Fiori, Matteo Candidi, Alessio Avenanti
- Abstrakt
Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired associative stimulation (ccPAS) can increase the strength of functional connectivity between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike timing-dependent plasticity (STDP), leading to enhanced motor functions in young adults. However, whether this STDP-inducing protocol is effective in the aging brain remains unclear. In two groups of young and elderly healthy adults, we evaluated manual dexterity with the 9-hole peg task before and after ccPAS of the left PMv-M1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals or in a control task. Across age groups, we observed that the magnitude of MEP changes predicted larger behavioral improvements. These findings demonstrate that left PMv-to-M1 ccPAS induces functionally specific improvements in young adults’ manual dexterity and an increase in corticomotor excitability, but altered plasticity prevents the effectiveness of ccPAS in the elderly.
- Organisation(en)
- Institut für Klinische und Gesundheitspsychologie
- Externe Organisation(en)
- Università di Bologna, Massachussetts General Hospital, Università degli Studi di Roma La Sapienza, Università Campus Bio-Medico di Roma, Universidad Católica del Maule
- Journal
- Frontiers in Aging Neuroscience
- Band
- 15
- ISSN
- 1663-4365
- DOI
- https://doi.org/10.3389/fnagi.2023.1119508
- Publikationsdatum
- 02-2023
- Peer-reviewed
- Ja
- ÖFOS 2012
- 301408 Psychophysiologie, 501014 Neuropsychologie, 501011 Kognitionspsychologie
- Schlagwörter
- ASJC Scopus Sachgebiete
- Ageing, Cognitive Neuroscience
- Link zum Portal
- https://ucris.univie.ac.at/portal/de/publications/transcranial-corticocortical-paired-associative-stimulation-ccpas-over-ventral-premotormotor-pathways-enhances-action-performance-and-corticomotor-excitability-in-young-adults-more-than-in-elderly-adults(6b75801a-a99f-4440-8bc3-a93611a832a0).html