Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men

Autor(en)

Urs M Nater, Toni Whistler, William Lonergan, Tanja Mletzko, Suzanne D Vernon, Christine Heim

Abstrakt

We investigated peripheral blood mononuclear cell gene expression responses to acute psychosocial stress to identify molecular pathways relevant to the stress response. Blood samples were obtained from 10 healthy male subjects before, during and after (at 0, 30, and 60 min) a standardized psychosocial laboratory stressor. Ribonucleic acid (RNA) was extracted and gene expression measured by hybridization to a 20,000-gene microarray. Gene Set Expression Comparisons (GSEC) using defined pathways were used for the analysis. Forty-nine pathways were significantly changed from baseline to immediately after the stressor (p<0.05), implicating cell cycle, cell signaling, adhesion and immune responses. The comparison between stress and recovery (measured 30 min later) identified 36 pathways, several involving stress-responsive signaling cascades and cellular defense mechanisms. These results have relevance for understanding molecular mechanisms of the physiological stress response, and might be used to further study adverse health outcomes of psychosocial stress.

Organisation(en)

Externe Organisation(en)

Centers for Disease Control and Prevention

Journal

Biological Psychology

Band

82

Seiten

125-132

Anzahl der Seiten

8

ISSN

0301-0511

DOI

https://doi.org/10.1016/j.biopsycho.2009.06.009

Publikationsdatum

2009

Peer-reviewed

Ja

ÖFOS 2012

501010 Klinische Psychologie

Schlagwörter

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/impact-of-acute-psychosocial-stress-on-peripheral-blood-gene-expression-pathways-in-healthy-men(6c284e51-c5ef-4c6d-9803-f5e1cb2cba26).html