Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women

Autor(en)

Verena Metz, Reinhold Jagsch, Nina Ebner, Johanna Würzl, Anna Pribasnig, Constantin Aschauer, Gabriele Fischer

Abstrakt

Objective The objective of this study is to compare maternal and neonatal outcome of opioid-dependent women maintained on buprenorphine

or methadone throughout pregnancy in a randomized double-blind double-dummy clinical trial (CT) with a comparison group undergoing

a structured standard protocol (SP) at the Medical University of Vienna, Austria.

Methods One hundred and fourteen subjects were included in the analysis, with 77 in SP (n=51 methadone, n=26 buprenorphine), and

37 in CT (n=19 methadone, n=18 buprenorphine), comparing maternal concomitant consumption during third trimester, demographic

birth data, duration of treatment for neonatal abstinence syndrome (NAS), morphine dose for NAS treatment and length of hospital

stay (LOS).

Results Both study groups yielded healthy neonates with no significant demographic differences and equivalently low rates of positive maternal

urine toxicologies. However, NAS parameters were significantly better in CT regarding total medication dose administered to neonates

(p=0.014) and LOS (p=0.015). Superior results were achieved in buprenorphine compared with methadone-exposed neonates regarding gestational

age at birth (p=0.003), birth weight (p=0.011), total morphine dose administered (p=0.008), NAS treatment duration (p=0.008) and

LOS (p=0.001).

Conclusions Comparably favorable outcome for mothers and infants and efficacy and safety of opioid medications were shown in both

treatment approaches. Neonatal care could benefit from transferring successful CT procedures into clinical practice.

Organisation(en)

Institut für Klinische und Gesundheitspsychologie

Externe Organisation(en)

Medizinische Universität Wien

Journal

Human Psychopharmacology: Clinical and Experimental

Band

Seiten

412-421

Anzahl der Seiten

DOI

https://doi.org/10.1002/hup.1224

Publikationsdatum

2011

Peer-reviewed

ÖFOS 2012

501010 Klinische Psychologie

Schlagwörter

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