Use of slow-release oral morphine for the treatment of opioid dependence

Autor(en): D. Kraigher, Reinhold Jagsch, Wolfgang Gombas, Romana Ortner, Harald Eder, Andjela Primorac, Gabriele Fischer
Abstrakt: Aims: In addition to methadone, other synthetic opioids are now available for the treatment of opioid dependence. The study investigated the treatment satisfaction of oral slow-release morphine for maintenance therapy in opioid-dependent patients in an open-label 3-week study. Design: We evaluated the treatment satisfaction of oral slow-release morphine hydrochloride for 3 weeks in 110 patients meeting the diagnosis of opioid dependence (DSM-IV 304.0) or polysubstance dependence (DSM-IV 304.9). Measurements: Primary outcome measures were the study retention rate, urinalysis for additional illicit consumption other than heroin, cravings and withdrawal symptoms 24 h after the last intake of the medication (duration of action of treatment). Findings: In total, 103 patients completed the study, representing a retention rate of 94%. Patients reported significant improvements in somatic complaints, as well as significant reductions in heroin and cocaine cravings (p <0.0001) and in additional consumption of cocaine in supervised urinalysis (p = 0.0083). Additional illicit consumption of benzodiazepines remained unchanged. Conclusions: The high study retention rate implies a good acceptance of slow-release acting oral morphine. However, randomised, double-blind, double-dummy studies with a longer investigational period are needed to meet criteria for evidence-based medicine. Copyright Œ 2005 S. Karger AG.
Organisation(en)
Externe Organisation(en): Medizinische Universität Wien
Journal: European Addiction Research
Band: 11
Seiten: 145-151
Anzahl der Seiten: 7
ISSN: 1022-6877
DOI: https://doi.org/10.1159/000085550
Publikationsdatum: 2005
Peer-reviewed: Ja
ÖFOS 2012: 5010 Psychologie
Link zum Portal: https://ucrisportal.univie.ac.at/de/publications/540cf82d-01bb-4d96-98be-0551023cf7dc