Physiological Stress Reactivity and Self-Harm: A Meta-Analysis

Autor(en)

Andreas Goreis, Karin Prillinger, Carolin Bedus, Ronja Lipp, Anna Mayer, Urs Markus Nater, Julian König, Paul L. Plener, Oswald D. Kothgassner

Abstrakt

Objective
Self-harm is associated with alterations in the psychobiological stress response. Specifically, the reactivity of the autonomic nervous system (ANS) and the endocrine hypothalamic-pituitary-adrenal (HPA) axis may differ in individuals who engage in self-harm. However, evidence in this regard is inconsistent.
Background
We conducted a preregistered random-effects meta-analysis of sympathetic ANS, parasympathetic ANS, sympathetic-parasympathetic, i.e., mixed-influence ANS, and HPA axis reactivity following laboratory stress exposure in individuals who engage in self-harm and controls. Stress exposure consisted of paradigms using either social-evaluative (e.g., TSST), emotional (e.g., negatively valenced visual stimuli), or physical (e.g., cold pressor test) challenges. A total of 29 studies (self-harm: n = 954, controls: n = 1122, 74% females) were included in the analysis.
Results
Regarding ANS reactivity to stress, no differences emerged between the two groups. However, parasympathetic ANS activity was lower before stress (g = −0.30, CI −0.51 to −0.09) and after stressor cessation (g = 0.54, CI −1.07 to −0.01) in the self-harm group compared to controls. Regarding HPA axis reactivity, individuals who engage in self-harm showed significantly lower cortisol responses to stress than did controls (g = −0.26, CI −0.45 to −0.08). After stressor cessation (i.e., during stress recovery), cortisol was also lower in individuals who engage in self-harm compared to controls (g = −0.26, CI −0.43 to −0.08).
Conclusions
Lower basal parasympathetic ANS activity and flattened cortisol responses indicate dysregulation of psychobiological stress systems in individuals who engage in self-harm. A better understanding of the psychobiological underpinnings of self-harm may allow for the establishment of biomarkers of risk stratification and treatment monitoring in affected individuals.

Organisation(en)

Institut für Klinische und Gesundheitspsychologie, Forschungsplattform The Stress of Life - Processes and Mechanisms underlying Everyday Life Stress

Externe Organisation(en)

Medizinische Universität Wien, Universität zu Köln, Universitätsklinikum Ulm

Journal

Psychoneuroendocrinology

Band

158

ISSN

0306-4530

DOI

https://doi.org/10.1016/j.psyneuen.2023.106406

Publikationsdatum

09-2023

Peer-reviewed

Ja

ÖFOS 2012

501010 Klinische Psychologie

Schlagwörter

ASJC Scopus Sachgebiete

Endocrine and Autonomic Systems, Psychiatry and Mental health, Biological Psychiatry, Endocrinology, Endocrinology, Diabetes and Metabolism

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/physiological-stress-reactivity-and-selfharm-a-metaanalysis(7232f2a2-b08b-455f-99bd-df4a915eb5fb).html