Neuroendocrine and immune contributors to fatigue

Autor(en)

Marni N Silverman, Christine M Heim, Urs Markus Nater, Andrea H Marques, Esther M Sternberg

Abstrakt

Central fatigue, a persistent and subjective sense of tiredness, generally correlates poorly with traditional markers of disease. It is frequently associated with psychosocial factors, such as depression, sleep disorder, anxiety, and coping style, which suggest that dysregulation of the body's stress systems may serve as an underlying mechanism in the maintenance of chronic fatigue (CF). This article addresses the endocrine, neural, and immune factors that contribute to fatigue and describes research regarding the role of these factors in chronic fatigue syndrome as a model for addressing the biology of CF. In general, hypoactivity of the hypothalamic-pituitary-adrenal axis, autonomic nervous system alterations characterized by sympathetic overactivity and low vagal tone, as well as immune abnormalities, may contribute to the expression of CF. Noninvasive methods for evaluating endocrine, neural, and immune function are also discussed. Simultaneous evaluation of neuroendocrine and immune systems with noninvasive techniques will help elucidate the underlying interactions of these systems, their role in disease susceptibility, and progression of stress-related disorders.

Organisation(en)

Externe Organisation(en)

Universität Zürich (UZH), Centers for Disease Control and Prevention, National Institutes of Health (NIH), Emory University

Journal

PM&R The journal of injury, function and rehabilitation

Band

2

Seiten

338-346

Anzahl der Seiten

9

ISSN

1934-1482

DOI

https://doi.org/10.1016/j.pmrj.2010.04.008

Publikationsdatum

2010

Peer-reviewed

Ja

ÖFOS 2012

501010 Klinische Psychologie

Schlagwörter

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/c39f839b-07a7-4aa0-9147-a9e6fa23d090