Opioid addiction changes cerebral blood flow symmetry
- Autor(en)
- Lukas Pezawas, Gabriele Fischer, Thomas Brücke, Reinhold Jagsch, Sabine Kasper
- Abstrakt
Changes in regional cerebral blood flow (rCBF) due to long-term abuse of opioids such as heroin or morphine are not yet fully understood in humans. The goal of the present study was to investigate rCBF alterations in a large sample of long-term opioid addicts in comparison to healthy controls. We investigated 21 opioid-dependent subjects, who were currently abusing heroin or were enrolled in a methadone or morphine maintenance program, and 36 healthy controls with 99mTc-HMPAO single photon emission computed tomography. We found a decrease in rCBF in most regions of interest in patients in comparison to controls. Long-term opioid dependence seems to decrease prefrontal CBF in particular. A right-greater-than-left CBF asymmetry in healthy subjects was reversed in patients. This change in CBF symmetry could reflect the different emotional status of opioid-dependent patients. Our findings are in line with neuropsychological investigations indicating a correlation of mood states with lateralization of hemispheric activation patterns. Copyright Π2002 S. Karger AG, Basel.
- Organisation(en)
- Externe Organisation(en)
- Wilhelminenspital
- Journal
- Neuropsychobiology: international journal of experimental and clinical research in biological psychiatry, pharmacopsychiatry, biological psychology, pharmacopsychology and pharmacoelectroencephalograp
- Band
- 45
- Seiten
- 67-73
- Anzahl der Seiten
- 7
- ISSN
- 0302-282X
- DOI
- https://doi.org/10.1159/000048679
- Publikationsdatum
- 2002
- Peer-reviewed
- Ja
- ÖFOS 2012
- 5010 Psychologie
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/e623f69f-2898-4256-ba8e-38669e95fd33