Opioid plasma concentrations in methadone- and buprenorphine-maintained patients

Autor(en)

Reinhold Jagsch, Shird-Dieter Schindler, David E. Moody, Gabriele Fischer

Abstrakt

This is the first trial to compare the relationship of opioid plasma concentrations in methadone- versus buprenorphine-maintained subjects. Sixty subjects (19 females and 41 males) seeking treatment who met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for opioid dependence were recruited and treated at the Drug Addiction Outpatient Clinic at the University of Vienna. Of these, 44 (11 female and 33 male) were included in the analyses of plasma concentrations. Subjects received either daily sublingual buprenorphine (2 mg or 8 mg tablets; maximum daily dose: 8 mg) or oral methadone (racemic R-/S-methadone) and were maintained on a stable dose after an induction period of 2 weeks. Mean dose and mean plasma concentrations were correlated on an individual and collective basis. Correlation was 0.51 for buprenorphine, whereas the score for methadone was 0.69. Intra-individual variation was much higher for buprenorphine (p <0.0001), while the concentration-to-dose ratio was very small. Based on the differences of the pharmacokinetics of blood plasma of the two agents, we tried to explain the differences in the acceptance of treatment, which was significantly lower in the buprenorphine-maintained group. No such differences could be evaluated between completers and dropouts in buprenorphine-maintained subjects, neither concerning withdrawal scores nor dose, plasma concentration, concentration-to-dose ratios or intra-individual variation. ΠSociety for the Study of Addiction to Alcohol and Other Drugs.

Organisation(en)

Externe Organisation(en)

Medizinische Universität Wien, University of Utah

Journal

Addiction Biology

Band

10

Seiten

365-371

Anzahl der Seiten

7

ISSN

1355-6215

Publikationsdatum

2005

Peer-reviewed

Ja

ÖFOS 2012

5010 Psychologie

Sustainable Development Goals

SDG 3 – Gesundheit und Wohlergehen

Link zum Portal

https://ucris.univie.ac.at/portal/de/publications/opioid-plasma-concentrations-in-methadone-and-buprenorphinemaintained-patients(fc286279-8c61-43e7-b64d-3176f463406d).html