Dopaminergic and opioidergic regulation during anticipation and consumption of social and nonsocial rewards

Autor(en)
Sebastian Korb, Sebastian J. Götzendorfer, Claudia Massaccesi, Patrick Sezen, Irene Graf, Matthäus Willeit, Christoph Eisenegger, Giorgia Silani
Abstrakt

The observation of animal orofacial and behavioral reactions has played a fundamental role in research on reward but is seldom assessed in humans. Healthy volunteers (N = 131) received 400 mg of the dopaminergic antagonist amisulpride, 50 mg of the opioidergic antagonist naltrexone, or placebo. Subjective ratings, physical effort, and facial reactions to matched primary social (affective touch) and nonsocial (food) rewards were assessed. Both drugs resulted in lower physical effort and greater negative facial reactions during reward anticipation, especially of food rewards. Only opioidergic manipulation through naltrexone led to a reduction in positive facial reactions to liked rewards during reward consumption. Subjective ratings of wanting and liking were not modulated by either drug. Results suggest that facial reactions during anticipated and experienced pleasure rely on partly different neurochemical systems, and also that the neurochemical bases for food and touch rewards are not identical.

Organisation(en)
Institut für Psychologie der Kognition, Emotion und Methoden, Institut für Klinische und Gesundheitspsychologie
Externe Organisation(en)
University of Essex, Medizinische Universität Wien
Journal
eLife
Band
9
ISSN
2050-084X
DOI
https://doi.org/10.7554/eLife.55797
Publikationsdatum
10-2020
Peer-reviewed
Ja
ÖFOS 2012
501014 Neuropsychologie
Link zum Portal
https://ucris.univie.ac.at/portal/de/publications/dopaminergic-and-opioidergic-regulation-during-anticipation-and-consumption-of-social-and-nonsocial-rewards(253fc22d-769c-478a-b421-252457c79507).html