Routine laboratory parameters to support decision on parenteral nutrition in palliative care

Autor(en)

Lea Kum, Elisabeth Lucia Zeilinger, Dagmar Vohla, Anna Kitta, Nadine Brunevskaya, Feroniki Adamidis, Franziska Ecker, Eva Katharina Masel, Brigitte Mayr-Pirker, Alexa Meyer, Bärbel Sturtzel, Gudrun Kreye, Matthias Unseld

Abstrakt

Introduction: Parenteral nutrition (PN) is widely used in palliative care (PC), but there is limited evidence to support its use at the end of life (EOL). This aim of this was to investigate the relationship between routine laboratory parameters and survival in patients receiving PN, and to develop a decision tree model to support clinicians decide whether to start or forgo PN. Methods: The laboratory parameters of 113 patients with advanced diseases who were admitted to a specialized palliative care unit (PCU) were analyzed at two points in time: T0 = before PN, T1 = two weeks after initiation of PN. Univariate Mann-Whitney U-tests and multivariate linear regression models, as well as a decision tree analysis were computed; all in relation to survival time. Results: The final regression model was significant with p = 0.001 (adjusted R2 = 0.15) and included two predictors for survival time after PN initiation: the CRP/albumin ratio and urea at T1 (ps = 0.019). Decision tree analysis revealed three important predictors for classification of survival time after PN initiation: CRP, urea, and LDH (all at T0). Discussion: The decision tree model may help to identify patients likely to benefit from PN, thus supporting the clinical decision whether or not to start PN.

Organisation(en)

Institut für Klinische und Gesundheitspsychologie

Externe Organisation(en)

Akademie für Altersforschung am Haus der Barmherzigkeit, Paracelsus Medizinische Privatuniversität (PMU), Karl Landsteiner Privatuniversität für Gesundheitswissenschaften, Medizinische Universität Wien

Journal

Frontiers in Nutrition

Band

10

ISSN

2296-861X

DOI

https://doi.org/10.3389/fnut.2023.1173106

Publikationsdatum

11-2023

Peer-reviewed

Ja

ÖFOS 2012

302058 Palliativmedizin, 303009 Ernährungswissenschaften

Schlagwörter

ASJC Scopus Sachgebiete

Food Science, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism

Link zum Portal

https://ucrisportal.univie.ac.at/de/publications/9c7b9aae-a2da-44f0-856a-530316881907